The article first introduces the domestication approach, its origins, its key elements, and its general contributions and limitations. It then examines ways in which the domestication analysis could be developed. One issue concerns contemporary objects of study and research questions given developments in information and communication technologies since the earliest domestication studies. Other issues include developing the analysis of the centrality of ICTs in our lives. Where appropriate, these issues are illustrated by considering examples of the computer, the Internet, and the mobile phone. To illustrate how the domestication framework can inform wider academic and policy fields, the final section considers its contribution to debates about the digital divide.